4-Bromo-2,6-difluoroaniline → HCID 66996813, compound

HRID 2360460Notes

Reaction equation

HRID 2360460 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[CH2:11]([C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1)[CH3:12]>>[CH2:11]([C:13]1[CH:18]=[C:17]([C:2]2[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:12]

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 16427138(3-Ethylphenyl)boronic acid

Product 1

HCID 66996813HCID 66996813, compoundYield 79.5%

Procedure

The title compound (89 mg) was prepared from 4-bromo-2,6-difluoroaniline (100 mg, 0.48 mmol) and 3-ethylphenylboronic acid (99 mg, 0.6 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-f1eec99a95ae405e9920c2127e934541
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

Loading…