4-Bromo-2-fluoroaniline → HCID 66997656, compound

HRID 2360467Notes

Reaction equation

HRID 2360467 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[CH2:10]([O:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1)[CH2:11][CH2:12][CH3:13]>>[CH2:10]([O:14][C:15]1[CH:20]=[C:19]([C:2]2[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=2)[CH:18]=[CH:17][CH:16]=1)[CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 1230504-Bromo-2-fluoroanilineHCID 50841013-Butoxyphenylboronic Acid

Product 1

HCID 66997656HCID 66997656, compoundYield 52%

Procedure

The title compound (170 mg) was prepared from 4-bromo-2-fluoroaniline (240 mg, 1.26 mmol) and 3-butoxyphenylboronic acid (310 mg, 1.59 mmol) as a yellow liquid.

Sources & evidence

ORD record
ord-b9c63cc4352c4ef3af8380e0b47a172b
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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