4-Bromo-2-fluoroaniline → HCID 66997797, compound

HRID 2360468Notes

Reaction equation

HRID 2360468 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[CH:10]([O:13][C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1)([CH3:12])[CH3:11]>>[CH:10]1([O:13][C:14]2[CH:15]=[C:16]([C:2]3[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=3)[CH:17]=[CH:18][CH:19]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 1230504-Bromo-2-fluoroanilineHCID 50839323-Isopropoxybenzeneboronic acid

Product 1

HCID 66997797HCID 66997797, compoundYield 18%

Procedure

The title compound (230 mg) was prepared from 4-bromo-2-fluoroaniline (1 g, 5.26 mmol) and 3-isopropoxyphenylboronic acid (1.8 g, 6.84 mmol) as a yellow liquid.

Sources & evidence

ORD record
ord-8ecc7c1f926b4235be37934d5840ec21
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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