4-Bromo-3-fluoroaniline → HCID 66997761, compound

HRID 2360470Notes

Reaction equation

HRID 2360470 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[F:9].[CH2:10]([O:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1)[CH2:11][CH2:12][CH3:13]>>[CH2:10]([O:14][C:15]1[CH:20]=[C:19]([C:2]2[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[F:9])[CH:18]=[CH:17][CH:16]=1)[CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 8218484-Bromo-3-fluoroanilineHCID 50841013-Butoxyphenylboronic Acid

Product 1

HCID 66997761HCID 66997761, compoundYield 88.5%

Procedure

The title compound (241 mg) was prepared from 4-bromo-3-fluoroaniline (200 mg, 1.05 mmol) and 3-butoxyphenylboronic acid (265 mg, 1.4 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-b3910a6ae37f4e629c544399d20e42aa
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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