4-Bromo-3,5-difluoroaniline → HCID 66997822, compound

HRID 2360471Notes

Reaction equation

HRID 2360471 reaction equation
Br[C:2]1[C:8]([F:9])=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[F:10].[CH2:11]([O:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1)[CH2:12][CH2:13][CH3:14]>>[CH2:11]([O:15][C:16]1[CH:21]=[C:20]([C:2]2[C:8]([F:9])=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[F:10])[CH:19]=[CH:18][CH:17]=1)[CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 27362604-Bromo-3,5-difluoroanilineHCID 50841013-Butoxyphenylboronic Acid

Product 1

HCID 66997822HCID 66997822, compoundYield 62%

Procedure

The title compound (172 mg) was prepared from 4-bromo-3,5-difluoroaniline (200 mg, 1 mmol) and 3-butoxyphenyl boronic acid (242 mg, 1.2 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-29e58c6cb34e46f5b400d669a827bbbc
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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