4-Bromo-2-fluoroaniline → HCID 66997259, compound

HRID 2360472Notes

Reaction equation

HRID 2360472 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1B(O)O>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1

Participants

3

Reactant 2

HCID 1230504-Bromo-2-fluoroanilineHCID 17750233(2-Chloro-5-methoxyphenyl)boronic acid

Product 1

HCID 66997259HCID 66997259, compoundYield 67.4%

Procedure

The title compound (134 mg) was prepared from 4-bromo-2-fluoroaniline (150 mg, 0.79 mmol) and 2-chloro-5-methoxylphenylboronic acid (191 mg, 1.02 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-dea10f1ea3f14c20a21d8ad88a4ade95
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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