Triethylamine → HCID 58493979, compound

Participants

Reaction Steps

Argon is piped for 10 minutes through a suspension of 18.8 g 7-bromo-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide in 250 ml of methanol and 50 ml N,N-dimethylformamide. Then 7.2 ml triethylamine and 2.3 g [1,1′-bis(diphenylphosphino)ferrocene]-palladium-II-dichloride-dichloromethane complex are added and 2 bar of carbon monoxide are compressed in for 15 hours at 80° C. Then the solvents are eliminated in vacuo, the residue is taken up in ethyl acetate and washed with 1 N hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated aqueous sodium chloride solution. After drying with magnesium sulphate the solvent is eliminated in vacuo and the residue is extracted from methanol. The solid is suction filtered, washed with a little methanol and dried.

Provenance & Evidence