Sodium Bicarbonate → HCID 58493950, compound

Participants

Reaction Steps

Tert-butyl 4-[2-(5-isobutyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperazine-1-carboxylate is used instead of tert-butyl [5-tert-butyl-2-methoxy-3-({1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carbonyl}-amino)-phenyl]-carbamate. The crude product is divided between dichloromethane and saturated aqueous sodium hydrogen carbonate solution. The aqueous phase is extracted with dichloromethane. The combined organic phases are dried on magnesium sulphate and the solvents are eliminated in vacuo. The product thus obtained is further reacted directly.

Provenance & Evidence