Potassium Carbonate → HCID 58493994, compound

Participants

Reaction Conditions

Reaction Steps

200 mg (S)-1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carboxylic acid-(5-tert-butyl-3-hydroxymethyl-2-methoxy-phenyl)-amide are dissolved in 5 ml dichloromethane, cooled to 0° C. and combined with 167 mg 1,1-dihydro-1,1,1-triacetoxy-1,2-benziodoxol-3(1H)-one (Dess-Martin-Periodinane). The mixture is stirred for 12 hours, while being heated to ambient temperature. Then it is divided between dichloromethane and a 10% aqueous potassium carbonate solution. A solid is precipitated which is filtered off. The liquid phases are separated and the organic phase is dried on magnesium sulphate. The solvents are then eliminated in vacuo. The product thus obtained is further reacted directly.

Provenance & Evidence