Sodium Hydroxide → HCID 66769308, compound

Participants

Reaction Steps

1.29 g methyl 5-tert-butyl-2-methoxy-3-({1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carbonyl}-amino)-benzoate are dissolved in 25 ml of tetrahydrofuran, combined with 4 ml of 4 N sodium hydroxide solution and heated for 2 hours to 40° C. Then the mixture is heated for 12 hours to 60° C., then a further 2 ml of 4 N sodium hydroxide solution are added and the mixture is heated for a further 12 hours to 60° C. It is then evaporated down in vacuo, the residue is taken up in water and the pH is adjusted to 5 by the addition of 4 N hydrochloric acid. It is extracted 5 times with dichloromethane/isopropanol 4:1 and the combined organic phases are dried on magnesium sulphate. The solvents are eliminated in vacuo and the product thus obtained is further reacted directly.

Provenance & Evidence