Sodium methanethiolate → 5-Tert-butyl-2-methoxy-1-methylsulphanylmethyl-3-nitro-benzene

Participants

Reaction Steps

4.64 g 5-tert-butyl-2-methoxy-3-nitro-benzyl methanesulphonate are dissolved in 50 ml of 1,4-dioxane, combined with 950 mg of sodium thiomethanolate and stirred for 12 hours at ambient temperature. A further 600 mg of sodium thiomethoxide are added and the mixture is stirred for 2 hours at 40° C. Then the solvents are eliminated in vacuo and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 98:2 to 60:40).

Provenance & Evidence