(3R)-(+)-3-(Dimethylamino)pyrrolidine → HCID 46190507, compound

HRID 2360522Notes

Reaction equation

HRID 2360522 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[C:8]([O:34][CH3:35])=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:33])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:23][N:24]2[CH2:29][CH2:28][CH:27]([C:30](O)=[O:31])[CH2:26][CH2:25]2)=[O:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:41][N:42]([CH3:48])[C@@H:43]1[CH2:47][CH2:46][NH:45][CH2:44]1>>[C:1]([C:5]1[CH:6]=[C:7]([NH:36][S:37]([CH3:40])(=[O:38])=[O:39])[C:8]([O:34][CH3:35])=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:33])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:23][N:24]2[CH2:25][CH2:26][CH:27]([C:30]([N:45]3[CH2:46][CH2:47][C@@H:43]([N:42]([CH3:48])[CH3:41])[CH2:44]3)=[O:31])[CH2:28][CH2:29]2)=[O:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2758521(3R)-(+)-3-(Dimethylamino)pyrrolidineHCID 58493998HCID 58493998, compound

Product 1

HCID 46190507HCID 46190507, compound

Procedure

1-[2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperidine-4-carboxylic acid and (R)-3-dimethylamino-pyrrolidine are used as reactants.

Sources & evidence

ORD record
ord-416841d22d3d47fead2ec2ca974afd00
Source dataset
uspto-grants-2014_04
Patent number
US08686022B2

Reaction notes

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