Hydrochloric Acid → HCID 46189904, compound

Participants

Reaction Steps

160 mg tert-butyl 4-(2-{4-[2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperazin-1-yl}-2-oxo-ethyl)-piperazine-1-carboxylate are dissolved in 5 ml dichloromethane, combined with 1 ml of a 5 M solution of hydrogen chloride in isopropanol and stirred for 12 hours at ambient temperature. Then the solvents are eliminated in vacuo and the residue is divided between saturated aqueous sodium hydrogen carbonate solution and ethyl acetate. The organic phase is washed with saturated aqueous sodium chloride solution and then dried on magnesium sulphate. The solvent is eliminated in vacuo and the residue is chromatographed on aluminium oxide (dichloromethane/methanol 100:0 to 95:5).

Provenance & Evidence