1-Methylpiperazine → HCID 46189950, compound

Participants

Reaction Steps

160 mg of (S)-1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carboxylic acid-(5-tert-butyl-3-formyl-2-methoxy-phenyl)-amide are dissolved in 2 ml of 1,2-dichloroethane, combined successively with 40 μl acetic acid and 45 μl of 1-methylpiperazine and stirred for 1 hour at ambient temperature. Then 70 mg of sodium triacetoxyborohydride are added and the mixture is stirred for 5 hours. Then it is divided between dichloromethane and saturated aqueous sodium hydrogen carbonate solution and the organic phase is washed with saturated aqueous sodium chloride solution. After drying with magnesium sulphate the solvents are eliminated in vacuo and the residue is purified by preparative HPLC (method 7).

Provenance & Evidence