Triethylamine → HCID 46190291, compound

Participants

Reaction Steps

70 mg (S)-1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carboxylic acid-(3-amino-2-methoxy-5-pentafluoroethyl-phenyl)-amide are dissolved in 2 ml dichloromethane, combined with 36 μl triethylamine, and 20 μl methanesulphonic acid chloride are added dropwise to this mixture. It is stirred for 2 hours, a further 20 μl methanesulphonic acid chloride and 36 μl triethylamine are added and then it is stirred for 1.5 hours. Then 2 ml of methanol and 600 μl of 2 N sodium hydroxide solution are added. The mixture is stirred for 2 hours, the solvents are eliminated in vacuo and the residue is chromatographed on silica gel (dichloromethane/(methanol/ammonia in methanol (saturated) 9:1) 99:1 to 85:15).

Provenance & Evidence