Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2360563생성일: 2026년 10월 25일
Triethylamine → Tert-butyl 9-[5-(methoxycarbonyl)pyridin-2-yl]-3,9-diazaspiro[5.5]undecane-3-carboxylate
https://huagongshe.com/reaction/2360563
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Methyl 6-chloropyridine-3-carboxylate | HCID 254249 | — |
| 반응물 | tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate | HCID 15296367 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Tert-butyl 9-[5-(methoxycarbonyl)pyridin-2-yl]-3,9-diazaspiro[5.5]undecane-3-carboxylate | HCID 57717452 | — |
반응 단계
A mixture of methyl 6-chloronicotinate (800 mg, 3.15 mmol), NEt3 (1.00 mL, 7.19 mmol) and tert-butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate (1.00 g, 3.94 mmol) in 5 mL of DMSO was heated to 100° C. for 1 h with microwave irradiation. The reaction mixture was poured into EtOAc and washed with 2 N NaOH, 2H HCl, brine and dried (Na2SO4), filtered and concentrated giving tert-butyl 9-[5-(methoxycarbonyl)pyridin-2-yl]-3,9-diazaspiro[5.5]undecane-3-carboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08686020B2 |
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| 출처 데이터셋 | uspto-grants-2014_04 |
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| ORD ID | ord-35bf12e18f604ac79d1b392937ea52ad |
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| 출처 메모 | uspto-grants-2014_04 |
|---|
