Trifluoroacetic acid → HCID 59631180, compound

Participants

Reaction Steps

To a stirred solution of 7-fluoro-N-(4-methoxybenzyl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine (0.486 g, 1.30 mmol) in dichloromethane (13.0 mL) was added TFA (0.5 mL, 6.49 mmol). Stirring continued at 23° C. for 26 hours. After which, the reaction was concentrated in vacuo, dissolved in ethyl acetate and washed with a saturated solution of sodium bicarbonate. The combined organic layers were concentrated in vacuo and purified on silica gel eluting with 0-10% methanol in dichloromethane to give the desired product 7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine. Mass Spectrum (ESI) m/e=254.1 (M+1).

Provenance & Evidence