HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 236064Generated: October 26, 2026
Pyridine → 4-(acetylamino)-N-(2,6-dimethylphenyl)benzamide
https://huagongshe.com/reaction/236064
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Ameltolide | HCID 13086 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(acetylamino)-N-(2,6-dimethylphenyl)benzamide | HCID 443227 | 85% |
Reaction Steps
To a solution of 2.0 g of 4-amino-N-(2,6-dimethylphenyl)benzamide in dimethylformamide were added 1 ml of pyridine followed by 710 μl of acetyl chloride. The reaction was stirrred at room temperature for 2 hours, diluted with water, and chilled to approximately 4° C. The title product was recovered by filtration in 85% yield, m.p. 293°-295° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04642379 |
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| Source dataset | uspto-grants-1987_02 |
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| ORD ID | ord-0da184272f6b474bb5fac4687f8f7171 |
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| Source note | uspto-grants-1987_02 |
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