Dimethylamine → HCID 13773219, compound

Participants

Reaction Steps

A mixture of 3.0 g of 4-[(chloroacetyl)amino]-N-(2,6-dimethylphenyl)benzamide and 22 ml of 40% aqueous dimethylamine in tetrahydrofuran was stirred at room temperature overnight. After the reaction was evaporated to dryness, the residue was taken up in chloroform, washed with 10% aqueous sodium carbonate, water, and a saturated sodium chloride solution, dried over sodium sulfate, and evaporated to dryness. Crystallization from methanol/water provided 2.8 g of the desired title product, m.p. 276°-278° C.

Provenance & Evidence