Sodium Sulfate → HCID 53492724, compound

Participants

Reaction Steps

0.5 g (1.57 mmol) of 2-[6-(2-pyridin-3-ylthiazol-5-yl)pyridin-2-yl]pyrimidine was dissolved in acetonitrile, 1.16 g (3.15 mmol) of 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate (Selectfluor™) and 1 g (7.04 mmol) of sodium sulphate were added and the mixture was heated at reflux overnight and, after cooling, filtered through Celite. The filtrate was concentrated and purified by chromatography (cyclohexane/ethyl acetate, then ethyl acetate/methanol).

Provenance & Evidence