Acetic Acid → HCID 178469359, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-5-methylpyrazole (50.0 g), diethyl oxalate sodium salt (127.3 g) and acetic acid (113 mL) in 1N aqueous hydrochloric acid (625 mL) was stirred at 80° C. for 14 h, then refluxed for 3 h, cooled to r.t., and the precipitate formed was filtered by suction filtration and dried in vacuo at 60° C. The crude product was stirred in 500 mL ethyl acetate at r.t. and the solid was filtered off and dried in air. 40.2 g (35%) of the title compound were obtained as pale yellow solid.

Provenance & Evidence