Sodium Hydroxide → HCID 86680297, compound

Participants

Reaction Steps

A mixture of 6-chloro-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester (25 g) and 1N sodium hydroxide solution (200 mL) in isopropanol (200 mL) was stirred at r.t. for 3 h. The solvent was distilled off, the residue was taken up in a little water and brought to pH 3-4 with 1N hydrochloric acid. A solid precipitated, which was filtered off and dried in air. 22 g (96%) of the title compound were obtained.

Provenance & Evidence