Hydrochloric Acid → HCID 178434396, compound

Participants

Reaction Steps

A mixture of 3-methyl-4-{3-methyl-1-(tetrahydropyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carbonyl}-3-phenyl-piperazine-1-carboxylic acid tert-butyl ester (300 mg) and HCl (4M in 1,4-dioxane, 104 μL) in dichloromethane (2 mL) was stirred at r.t. overnight. A solid precipitated during the reaction, which was filtered off and dried in air. The sticky solid was triturated with acetonitrile and filtered again, washed with acetonitrile and dried in air. 137 mg (64%) of the title compound were obtained as hydrochloride salt.

Provenance & Evidence