反应详情

To a solution of 6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (1-benzyl-4-methyl-piperidin-4-yl)-amide (136 mg) in methanol (2 mL) was added palladium (10% on charcoal, 27 mg). Argon was purged through the mixture, then the mixture was saturated with hydrogen and stirred at r.t. overnight. The catalyst was filtered off, the residue was concentrated in vacuo, the residue was re-dissolved in fresh methanol (2 mL) and fresh palladium (10% on charcoal, 27 mg) was added. The mixture was again stirred at r.t. for 1 week. The catalyst was filtered off, the residue was concentrated in vacuo to give 75 mg (66%) of the title compound.

1. customArgon was purged through the mixture
2. filtrationThe catalyst was filtered off
3. concentrationthe residue was concentrated in vacuo
4. dissolutionthe residue was re-dissolved in fresh methanol (2 mL)
5. additionfresh palladium (10% on charcoal, 27 mg) was added
6. stirringThe mixture was again stirred at r.t. for 1 week
7. filtrationThe catalyst was filtered off
8. concentrationthe residue was concentrated in vacuo