HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → HCID 178519319, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Methyl pyruvate | HCID 11748 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 3-cyclopropyl-1H-pyrazol-5-amine | HCID 2758014 | — |
| Reactant | HCID 178434395 | HCID 178434395 | — |
| Reactant | HCID 178524129 | HCID 178524129 | — |
| Product | HCID 178519319 | HCID 178519319 | — |
Reaction Steps
[3-Cyclopropyl-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone was prepared following a similar procedure as described for the synthesis of example 53, [6-(4-Hydroxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone, using 3-cyclopropyl-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (obtained as described in example 41, steps (a) and (c) employing 5-cyclopropyl-1H-pyrazol-3-ylamine, pyruvic acid methyl ester and 4-hydroxybenzaldehyde as the starting materials) and tert.butyl 1-piperazine carboxylate as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686150B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a8e747af503b4964a373dca7f01fbf31 |
| Source note | uspto-grants-2014_04 |