Water → HCID 86680334, compound

HRID 2360711Notes

Reaction equation

HRID 2360711 reaction equation
[NH2:1][CH2:2][C:3](N)([CH3:5])[CH3:4].O[C:8]1([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9]1.[OH2:15]>>[CH3:4][C:3]1([CH3:5])[NH:14][C:13](=[O:15])[C:8]2([CH2:12][CH2:11][CH2:10][CH2:9]2)[NH:1][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 131282-MethylpropylenediamineHCID 1998551-Hydroxycyclopentanecarbonitrile

Product 1

HCID 86680334HCID 86680334, compoundYield 90%

Procedure

To a solution of 6.1 ml of 1,2-diamino-2-methylpropane in 17 ml water 5.7 ml of 1-hydroxycyclopentane-1-carbonitrile was slowly added. The reaction was kept at reflux for 48 h, and the cooled to r.t. The precipitated product was isolated by suction and washed with water. From the filtrate additional solid could be obtained. The combined solids were freeze-dried and 9.32 g (90%) of the title compound were obtained, which could be used in the next step without further purification.

Workup

  1. temperatureat reflux for 48 h
  2. customThe precipitated product was isolated by suction
  3. washwashed with water
  4. customFrom the filtrate additional solid could be obtained
  5. customThe combined solids were freeze-dried

Sources & evidence

ORD record
ord-77059c475ed44b2bb4590e562099a351
Source dataset
uspto-grants-2014_04
Patent number
US08686150B2

Reaction notes

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