反应详情

To a solution of 6.1 ml of 1,2-diamino-2-methylpropane in 17 ml water 5.7 ml of 1-hydroxycyclopentane-1-carbonitrile was slowly added. The reaction was kept at reflux for 48 h, and the cooled to r.t. The precipitated product was isolated by suction and washed with water. From the filtrate additional solid could be obtained. The combined solids were freeze-dried and 9.32 g (90%) of the title compound were obtained, which could be used in the next step without further purification.

1. temperatureat reflux for 48 h
2. customThe precipitated product was isolated by suction
3. washwashed with water
4. customFrom the filtrate additional solid could be obtained
5. customThe combined solids were freeze-dried