Perindopril → HCID 178448324, compound

HRID 2360729Notes

Reaction equation

HRID 2360729 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:13][CH2:14][CH2:15][C@H:16]([NH:22][C@H:23]([C:25]([N:27]1[C@H:35]([C:36]([OH:38])=[O:37])[CH2:34][C@H:33]2[C@@H:28]1[CH2:29][CH2:30][CH2:31][CH2:32]2)=[O:26])[CH3:24])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>O>[CH3:13][CH2:14][CH2:15][C@H:16]([NH:22][C@H:23]([C:25]([N:27]1[C@H:35]([C:36]([OH:38])=[O:37])[CH2:34][C@H:33]2[C@@H:28]1[CH2:29][CH2:30][CH2:31][CH2:32]2)=[O:26])[CH3:24])[C:17]([O:19][CH2:20][CH3:21])=[O:18].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

4

Reactant 2

HCID 107807PerindoprilHCID 178418600HCID 178418600, compound

Product 1

HCID 178448324HCID 178448324, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In one of the embodiments of the present invention, Perindopril free acid is dissolved in water to get clear solution at room temperature. (L)-Arginine is added to the solution and it is maintained for 15 to 30 minutes at room temperature. The solvent is removed by using techniques such as vacuum distillation, freeze drying and spray drying to obtain the polymorphic form γ of Perindopril (L)-Arginine.

Workup

  1. customto get clear solution at room temperature
  2. customThe solvent is removed
  3. distillationsuch as vacuum distillation, freeze
  4. customdrying
  5. customspray drying

Sources & evidence

ORD record
ord-d5888f7b14264f668ffb1e9bddb1db1c
Source dataset
uspto-grants-2014_04
Patent number
US08686161B2

Reaction notes

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