HRID2360729

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)OCC

HCID107807

Perindopril

C19H32N2O5

HCID178418600

未命名化合物

PRODUCTS

产物

反应SMILES：CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)OCC.N=C(N)NCCC[C@H](N)C(=O)O

HCID178448324

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In one of the embodiments of the present invention, Perindopril free acid is dissolved in water to get clear solution at room temperature. (L)-Arginine is added to the solution and it is maintained for 15 to 30 minutes at room temperature. The solvent is removed by using techniques such as vacuum distillation, freeze drying and spray drying to obtain the polymorphic form γ of Perindopril (L)-Arginine.

WORKUP

后处理

customto get clear solution at room temperature
customThe solvent is removed
distillationsuch as vacuum distillation, freeze
customdrying
customspray drying

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-d5888f7b14264f668ffb1e9bddb1db1c
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08686161B2
来源说明: uspto-grants-2014_04

反应SMILES

[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:13][CH2:14][CH2:15][C@H:16]([NH:22][C@H:23]([C:25]([N:27]1[C@H:35]([C:36]([OH:38])=[O:37])[CH2:34][C@H:33]2[C@@H:28]1[CH2:29][CH2:30][CH2:31][CH2:32]2)=[O:26])[CH3:24])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>O>[CH3:13][CH2:14][CH2:15][C@H:16]([NH:22][C@H:23]([C:25]([N:27]1[C@H:35]([C:36]([OH:38])=[O:37])[CH2:34][C@H:33]2[C@@H:28]1[CH2:29][CH2:30][CH2:31][CH2:32]2)=[O:26])[CH3:24])[C:17]([O:19][CH2:20][CH3:21])=[O:18].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]