Acetone → HCID 178448324, compound

HRID 2360730Notes

Reaction equation

HRID 2360730 reaction equation
C(O)C.CC(C)=O.CCOCC.[NH2:13][C@H:14]([C:22]([OH:24])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:21])[NH2:20].[CH3:25][CH2:26][CH2:27][C@H:28]([NH:34][C@H:35]([C:37]([N:39]1[C@H:47]([C:48]([OH:50])=[O:49])[CH2:46][C@H:45]2[C@@H:40]1[CH2:41][CH2:42][CH2:43][CH2:44]2)=[O:38])[CH3:36])[C:29]([O:31][CH2:32][CH3:33])=[O:30]>O.O1CCOCC1>[CH3:25][CH2:26][CH2:27][C@H:28]([NH:34][C@H:35]([C:37]([N:39]1[C@H:47]([C:48]([OH:50])=[O:49])[CH2:46][C@H:45]2[C@@H:40]1[CH2:41][CH2:42][CH2:43][CH2:44]2)=[O:38])[CH3:36])[C:29]([O:31][CH2:32][CH3:33])=[O:30].[NH2:13][C@H:14]([C:22]([OH:24])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:20])[NH2:21]

Participants

8

Reactant 5

HCID 180AcetoneHCID 702EthanolHCID 3283Diethyl EtherHCID 107807PerindoprilHCID 178418600HCID 178418600, compound

Product 1

HCID 178448324HCID 178448324, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

In one of the embodiments of the present invention, Perindopril acid is dissolved in suitable solvent is selected from mixture of water and organic solvent. The organic solvent is selected from alcohol such as ethanol, ketone such as acetone, ether such as 1,4-dioxane. (L)-Arginine is dissolved in water to get solution is added to the above solution followed by stirring and filtration to give polymorphic form γ of Perindopril (L)-Arginine.

Workup

  1. customto get solution
  2. additionis added to the above solution
  3. filtrationfiltration

Sources & evidence

ORD record
ord-b88aac9001c841af88a6387c7ae87276
Source dataset
uspto-grants-2014_04
Patent number
US08686161B2

Reaction notes

Loading…