HRID2360730

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID180

Acetone

C3H6O

HCID702

Ethanol

C2H6O

HCID3283

Diethyl Ether

C4H10O

反应SMILES：CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)OCC

HCID107807

Perindopril

C19H32N2O5

HCID178418600

未命名化合物

PRODUCTS

产物

反应SMILES：CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)OCC.N=C(N)NCCC[C@H](N)C(=O)O

HCID178448324

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

2 次

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

In one of the embodiments of the present invention, Perindopril acid is dissolved in suitable solvent is selected from mixture of water and organic solvent. The organic solvent is selected from alcohol such as ethanol, ketone such as acetone, ether such as 1,4-dioxane. (L)-Arginine is dissolved in water to get solution is added to the above solution followed by stirring and filtration to give polymorphic form γ of Perindopril (L)-Arginine.

WORKUP

后处理

customto get solution
additionis added to the above solution
filtrationfiltration

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-b88aac9001c841af88a6387c7ae87276
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08686161B2
来源说明: uspto-grants-2014_04

反应SMILES

C(O)C.CC(C)=O.CCOCC.[NH2:13][C@H:14]([C:22]([OH:24])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:21])[NH2:20].[CH3:25][CH2:26][CH2:27][C@H:28]([NH:34][C@H:35]([C:37]([N:39]1[C@H:47]([C:48]([OH:50])=[O:49])[CH2:46][C@H:45]2[C@@H:40]1[CH2:41][CH2:42][CH2:43][CH2:44]2)=[O:38])[CH3:36])[C:29]([O:31][CH2:32][CH3:33])=[O:30]>O.O1CCOCC1>[CH3:25][CH2:26][CH2:27][C@H:28]([NH:34][C@H:35]([C:37]([N:39]1[C@H:47]([C:48]([OH:50])=[O:49])[CH2:46][C@H:45]2[C@@H:40]1[CH2:41][CH2:42][CH2:43][CH2:44]2)=[O:38])[CH3:36])[C:29]([O:31][CH2:32][CH3:33])=[O:30].[NH2:13][C@H:14]([C:22]([OH:24])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:20])[NH2:21]