Perindopril → HCID 178448324, compound

HRID 2360731Notes

Reaction equation

HRID 2360731 reaction equation
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH2:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:35])[NH2:34]>CO>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH2:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:34])[NH2:35]

Participants

4

Reactant 2

HCID 107807PerindoprilHCID 178418600HCID 178418600, compound

Product 1

HCID 178448324HCID 178448324, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

15 g of Perindopril was suspended in methanol (105 ml) at room temperature. To this solution (L)-Arginine (7.1 g) was added and heated to reflux to get clear solution. The resulting solution was filtered through hyflow bed to remove any undissolved particulate. The filtrate was cooled to room temperature and subjected to spray drying to give amorphous Perindopril (L)-Arginine.

Workup

  1. temperatureheated
  2. temperatureto reflux
  3. customto get clear solution
  4. filtrationThe resulting solution was filtered through hyflow bed
  5. customto remove any undissolved particulate
  6. customto spray drying

Sources & evidence

ORD record
ord-7d4804f5aae84965959a5a047ac65329
Source dataset
uspto-grants-2014_04
Patent number
US08686161B2

Reaction notes

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