反应详情

15 g of Perindopril was suspended in methanol (105 ml) at room temperature. To this solution (L)-Arginine (7.1 g) was added and heated to reflux to get clear solution. The resulting solution was filtered through hyflow bed to remove any undissolved particulate. The filtrate was cooled to room temperature and subjected to spray drying to give amorphous Perindopril (L)-Arginine.

1. temperatureheated
2. temperatureto reflux
3. customto get clear solution
4. filtrationThe resulting solution was filtered through hyflow bed
5. customto remove any undissolved particulate
6. customto spray drying