Methanol → HCID 178448324, compound

HRID 2360732Notes

Reaction equation

HRID 2360732 reaction equation
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].CO.O.[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37]>ClCCl>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 107807PerindoprilHCID 178418600HCID 178418600, compound

Product 1

HCID 178448324HCID 178448324, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10 g of Perindopril was suspended in a 1:1 mixture of methanol and water (5; 5 v/v) of dichloromethane (250 ml) at room temperature. To this solution (L)-Arginine (7.1 g) was added and heated to reflux to get clear solution. The resulting solution was filtered through hyflow bed to remove any undissolved particulate. The filtrate is then cooled to room temperature and subjected to spray drying to give amorphous Perindopril (L)-Arginine.

Workup

  1. temperatureheated
  2. temperatureto reflux
  3. customto get clear solution
  4. filtrationThe resulting solution was filtered through hyflow bed
  5. customto remove any undissolved particulate
  6. customto spray drying

Sources & evidence

ORD record
ord-4621dc0d61d24cc790d27e6a1484469f
Source dataset
uspto-grants-2014_04
Patent number
US08686161B2

Reaction notes

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