反应详情

温度

65 °C

5 g of Perindopril free acid and (L)-Arginine (2.3 g) is suspended in methanol (50 ml) at room temperature. The reaction mass was then refluxed to get the clear solution and stirred for 60 minutes at 60 to 70° C. The resulting solution was cooled to room temperature and then cooled to 0 to 5° C. To this solution IPE (1.0 lit) was added and then maintained for 1 hour at 0 to 5° C. The solid obtained is dried for 15 hours under vacuum at 50° C.

1. temperatureThe reaction mass was then refluxed
2. customto get the clear solution
3. temperatureThe resulting solution was cooled to room temperature
4. temperaturecooled to 0 to 5° C
5. additionTo this solution IPE (1.0 lit) was added
6. temperaturemaintained for 1 hour at 0 to 5° C
7. customThe solid obtained
8. customis dried for 15 hours under vacuum at 50° C.