反应详情

温度

17.5 °C

2 g of pure Perindopril free acid and (L)-Arginine (0.9 g) are dissolved in 10 ml of water at 25 to 30° C. To this clear solution indicated solvents at the indicated volumes was added at 25 to 30° C. and stirred for 30 minutes. The resulting solution was cooled to 15 to 20° C. and an indicated anti solvent at the indicated volumes are added slowly. The resulting reaction mass was stirred for 1 hour at 15 to 20° C. The solid was filtered and washed with 5 ml of indicated solvents. The wet solid was dried at 50 to 55° C. under vacuum for 12 hours. The results are shown in following table 4

1. additionwas added at 25 to 30° C.
2. additionare added slowly
3. customThe resulting reaction mass
4. stirringwas stirred for 1 hour at 15 to 20° C
5. filtrationThe solid was filtered
6. washwashed with 5 ml of indicated solvents
7. customThe wet solid was dried at 50 to 55° C. under vacuum for 12 hours