Perindopril → HCID 178448324, compound

HRID 2360734Notes

Reaction equation

HRID 2360734 reaction equation
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH2:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:35])[NH2:34]>O>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH2:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:34])[NH2:35]

Participants

4

Reactant 2

HCID 107807PerindoprilHCID 178418600HCID 178418600, compound

Product 1

HCID 178448324HCID 178448324, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
17.5 °C

Procedure

2 g of pure Perindopril free acid and (L)-Arginine (0.9 g) are dissolved in 10 ml of water at 25 to 30° C. To this clear solution indicated solvents at the indicated volumes was added at 25 to 30° C. and stirred for 30 minutes. The resulting solution was cooled to 15 to 20° C. and an indicated anti solvent at the indicated volumes are added slowly. The resulting reaction mass was stirred for 1 hour at 15 to 20° C. The solid was filtered and washed with 5 ml of indicated solvents. The wet solid was dried at 50 to 55° C. under vacuum for 12 hours. The results are shown in following table 4

Workup

  1. additionwas added at 25 to 30° C.
  2. additionare added slowly
  3. customThe resulting reaction mass
  4. stirringwas stirred for 1 hour at 15 to 20° C
  5. filtrationThe solid was filtered
  6. washwashed with 5 ml of indicated solvents
  7. customThe wet solid was dried at 50 to 55° C. under vacuum for 12 hours

Sources & evidence

ORD record
ord-d798a498237a491baff30cca26e3a430
Source dataset
uspto-grants-2014_04
Patent number
US08686161B2

Reaction notes

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