反应详情

1 g of pure Perindopril free acid was dissolved in 4.5 ml of water at 25 to 30° C. To this 0.47 g of (L)-Arginine was added and stirred for 10 min to get clear solution at 25 to 30° C. To this methylcyclohexane (2.5 ml) was added and stirred for 30 minutes at 25 to 30° C. DMSO (13 ml) was added slowly at room temperature. Solid immediately precipitated out, continue stirring for 30 minutes. The solid was filtered and dried at 50 to 55° C. under vacuum for 12 hours.

1. customto get clear solution at 25 to 30° C
2. stirringstirred for 30 minutes at 25 to 30° C
3. customSolid immediately precipitated out
4. stirringcontinue stirring for 30 minutes
5. filtrationThe solid was filtered
6. customdried at 50 to 55° C. under vacuum for 12 hours