Cyclohexane → HCID 178448324, compound

Participants

Reaction Conditions

Reaction Steps

5 g of Perindopril free acid was dissolved in 25 ml of water at 25 to 30° C. To this (L)-Arginine (2.3 g) was added and stirred for 10 minutes to get clear solution at 25 to 30° C. The reaction mass was cooled to 15 to 20° C. To this cold solution mixture of 12 ml of cyclohexane and 75 ml of dimethylacetamide were added slowly at 15 to 20° C. Solid immediately precipitated out, continue stirring for 1 hour at 15 to 20° C. The solid is filtered and washed with 5 ml of cyclohexane. The wet solid was dried at 50 to 55° C. under vacuum for 12 hours.

Provenance & Evidence