反应详情

温度

7.5 °C

Crude docetaxel (1.0 g) was dissolved in a mixture of ethanol:cyclohexane:demineralised water:ethyl acetate (20:2:10:0.8) containing 0.02 g potassium aluminum sulfate at 25-30° C. under constant stirring. The clear biphasic reaction was then concentrated to 20 ml and cooled to 5-10° C. The precipitated solid was stirred for 25-30 minutes at 5-10° C., then filtered, washed with demineralised water (1 ml) and dried under vacuum under a humid atmosphere (until the moisture content was between 5-7% by Karl Fischer method) to afford Docetaxel trihydrate in 70-90% yield.

1. customThe clear biphasic reaction
2. concentrationwas then concentrated to 20 ml
3. filtrationfiltered
4. washwashed with demineralised water (1 ml)
5. customdried under vacuum under a humid atmosphere (until the moisture content