Water → C43H53NO14.3H2O

Participants

Reaction Conditions

Reaction Steps

Crude docetaxel (1.0 g,) was dissolved in 1,4-dioxane (5 ml) at 25-30° C. under constant stirring. Demineralised water (7 ml) containing 0.02 g of potassium aluminum sulfate was added slowly at 25-30° C. with constant stirring. The precipitated solid was stirred for 25-30 minutes at 25-30° C., then filtered, washed with a 1:1 solution of 1,4-dioxane and demineralised water (1 ml), dried under vacuum under humid atmosphere (until the moisture content was between 5-7% by Karl Fischer method) to afford Docetaxel trihydrate in 70-90% yield

Provenance & Evidence