HCID 58294546, compound → HCID 67223871, compound

HRID 2360801Notes

Reaction equation

HRID 2360801 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[O:13]1[CH2:18][CH:17]=[C:16]([C:19]2[CH:20]=[CH:21][C:22]3[CH2:23][C@H:24]4[C@@H:29]([C:30]=3[CH:31]=2)[CH2:28][CH2:27][CH2:26][NH:25]4)[CH2:15][CH2:14]1>>[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:25]3[CH2:26][CH2:27][CH2:28][C@@H:29]4[C:30]5[CH:31]=[C:19]([C:16]6[CH2:17][CH2:18][O:13][CH2:14][CH:15]=6)[CH:20]=[CH:21][C:22]=5[CH2:23][C@H:24]34)=[O:12])=[CH:9][C:4]=2[NH:3][CH:2]=1

Participants

3

Reactant 2

HCID 58294546HCID 58294546, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 67223871HCID 67223871, compoundYield 69%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-6-(3,6-dihydro-2H-pyran-4-yl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1. Yield: 69% of theory; LC (method 1): tR=2.65 min; Mass spectrum (ESI+): m/z=400 [M+H]+.

Sources & evidence

ORD record
ord-41b6070800aa4f39b910a49f48595717
Source dataset
uspto-grants-2014_04
Patent number
US08686149B2

Reaction notes

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