HCID 58294528, compound → HCID 67223156, compound

HRID 2360802Notes

Reaction equation

HRID 2360802 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[C:13]1([C:18]2[CH:19]=[CH:20][C:21]3[CH2:22][C@H:23]4[C@@H:28]([C:29]=3[CH:30]=2)[CH2:27][CH2:26][CH2:25][NH:24]4)[CH2:17][CH2:16][CH2:15][CH:14]=1>>[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:24]3[CH2:25][CH2:26][CH2:27][C@@H:28]4[C:29]5[CH:30]=[C:18]([C:13]6[CH2:17][CH2:16][CH2:15][CH:14]=6)[CH:19]=[CH:20][C:21]=5[CH2:22][C@H:23]34)=[O:12])=[CH:9][C:4]=2[NH:3][CH:2]=1

Participants

3

Reactant 2

HCID 58294528HCID 58294528, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 67223156HCID 67223156, compoundYield 49%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-6-cyclopent-1-enyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1. Yield: 49% of theory; LC (method 1): tR=2.64 min; Mass spectrum (ESI+): m/z=384 [M+H]+.

Sources & evidence

ORD record
ord-0d592d2f2283458b8538ac7fd6a13b26
Source dataset
uspto-grants-2014_04
Patent number
US08686149B2

Reaction notes

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