HCID 86654094, compound → HCID 178519370, compound

HRID 2360824Notes

Reaction equation

HRID 2360824 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:13][C:14]1[C:19]2[C@@H:20]3[C@H:25]([CH2:26][CH2:27][C:18]=2[CH:17]=[CH:16][CH:15]=1)[NH:24][CH2:23][CH2:22][CH2:21]3>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:24]3[C@@H:25]4[C@@H:20]([C:19]5[C:14]([F:13])=[CH:15][CH:16]=[CH:17][C:18]=5[CH2:27][CH2:26]4)[CH2:21][CH2:22][CH2:23]3)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 86654094HCID 86654094, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178519370HCID 178519370, compoundYield 75%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-10-fluoro-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline following a procedure analogous to that described in Example 1. Yield: 75% of theory; LC (method 1): tR=2.66 min; Mass spectrum (ESI+): m/z=350 [M+H]+.

Sources & evidence

ORD record
ord-28c23aa709af44018089b98f892a8b6c
Source dataset
uspto-grants-2014_04
Patent number
US08686149B2

Reaction notes

Loading…