HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazo(1,2-a)pyridine-6-carboxylic acid → (cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridin-1-yl)-imidazo[1,2-a]pyridin-6-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazo(1,2-a)pyridine-6-carboxylic acid | HCID 7075376 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine | HCID 58123900 | — |
| Product | (cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridin-1-yl)-imidazo[1,2-a]pyridin-6-yl-methanone | HCID 67223439 | 85% |
Reaction Steps
The title compound is prepared from imidazo[1,2-a]pyridine-6-carboxylic acid and cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1 [2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexa-fluorophosphate is used]. Yield: 85% of theory; LC (method 3): tR=1.81 min; Mass spectrum (ESI+): m/z=318 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686149B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-c13076071b854b74be85b9502fca25ff |
| Source note | uspto-grants-2014_04 |