cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-7-ylamine → HCID 178507243, compound

HRID 2360933Notes

Reaction equation

HRID 2360933 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]2[C:19]3[CH:20]=[CH:21][C:22]([NH2:26])=[CH:23][C:24]=3[CH2:25][C@H:14]12>>[NH2:26][C:22]1[CH:21]=[CH:20][C:19]2[C@@H:15]3[C@@H:14]([N:13]([C:10]([C:8]4[CH:7]=[CH:6][C:5]5[NH:1][CH:2]=[N:3][C:4]=5[CH:9]=4)=[O:12])[CH2:18][CH2:17][CH2:16]3)[CH2:25][C:24]=2[CH:23]=1

Participants

3

Reactant 2

HCID 58294569cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-7-ylamineHCID 178524171HCID 178524171, compound

Product 1

HCID 178507243HCID 178507243, compoundYield 30%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-7-ylamine following a procedure analogous to that described in Example 1. Yield: 30% of theory; LC (method 1): tR=0.79 min; Mass spectrum (ESI+): m/z=333 [M+H]+.

Sources & evidence

ORD record
ord-6186f24034f94659a3533e7e3edce87b
Source dataset
uspto-grants-2014_04
Patent number
US08686149B2

Reaction notes

Loading…