HCID 58294460, compound → HCID 178422527, compound

HRID 2360940Notes

Reaction equation

HRID 2360940 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:13][C:14]1[CH:15]=[CH:16][C:17]2[CH2:18][C@H:19]3[C@@H:24]([C:25]=2[CH:26]=1)[CH2:23][CH2:22][CH2:21][NH:20]3>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:20]3[CH2:21][CH2:22][CH2:23][C@@H:24]4[C:25]5[CH:26]=[C:14]([CH3:13])[CH:15]=[CH:16][C:17]=5[CH2:18][C@H:19]34)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 58294460HCID 58294460, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178422527HCID 178422527, compoundYield 60%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-6-methyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1. Yield: 60% of theory; LC (method 1): tR=2.75 min; Mass spectrum (ESI+): m/z=332 [M+H]+.

Sources & evidence

ORD record
ord-589f53e4dc1f4a0c9d64609eab4e2062
Source dataset
uspto-grants-2014_04
Patent number
US08686149B2

Reaction notes

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