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2-Methyl-3-phenyl-1-propanol → Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-3-phenyl-1-propanol | HCID 95640 | — |
| 触媒 | Ferrous Chloride | HCID 24458 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 生成物 | Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl- | HCID 92013 | 84% |
反応手順
DE 29 52 719 likewise describes the iron chloride-catalyzed Friedel-Crafts alkylation of 2-methyl-3-phenylpropanol. In cyclohexane or dichloroethane as solvent, a yield of 84-86% of 2-methyl-3-(4-tert-butylphenyl)propanol was obtained. The formation of the m-isomeric compound (2-methyl-3-(3-tert-butylphenyl)propanol), was not demonstrated. A disadvantage of the described Friedel-Crafts alkylations is the small amount of the m-isomeric compound formed (m:p ratio is max. 1:5).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08686193B2 |
| 出典データセット | uspto-grants-2014_04 |
| ORD ID | ord-46c9d158b7d14f4eb5e4b74b90ffabd0 |
| 出典メモ | uspto-grants-2014_04 |