関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 2,4-Dihydroxy-3-methylbenzaldehyde | HCID 80395 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(Benzyloxy)-2-hydroxy-3-methylbenzaldehyde | HCID 59761690 | — |
反応手順
A mixture of 2,4-dihydroxy-3-methyl-benzaldehyde (3.31 g, 21.8 mmol), benzylbromide (4.09 g, 23.9 mmol), NaHCO3 (5.49 g, 65.4 mmol), 1,4-dioxane (30 mL) and water (12 mL) was stirred at 60° C. for overnight. Then the reaction mixture was cooled to RT, water (100 mL) was added, extracted with EtOAc (2×200 mL). The extract was dried over Na2SO4, evaporated. The residue was purified on SiO2 (25 g) column, hexane-EtOAc (0 to 5%). Yield 1.57 g (6.48 mmol, 29%) as off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08686005B2 |
|---|
| 出典データセット | uspto-grants-2014_04 |
|---|
| ORD ID | ord-392855616cfa4a6780a51f366183d291 |
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| 出典メモ | uspto-grants-2014_04 |
|---|
