2-Chloronicotinonitrile → 2-Methoxypyridine-3-carbonitrile

HRID 2361179Notes

Reaction equation

HRID 2361179 reaction equation
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:10][O:11][Na]>CO>[CH3:10][O:11][C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

4

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 178418582HCID 178418582, compound

Product 1

HCID 2520992-Methoxypyridine-3-carbonitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Methoxy-nicotinonitrile was prepared according to the literature by reaction of the 2-chloro-nicotinonitrile with MeONa in MeOH according to Dunn, A. D.; Norrie, R.; Heterocycl. Chem.; EN; 24; 1987; 85-89.

Sources & evidence

ORD record
ord-3c98e9c32b7040cf9e2b1211062e18b6
Source dataset
uspto-grants-2014_04
Patent number
US08686005B2

Reaction notes

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