反应详情

To a spatula full of Raney-Ni in a Parr tube was added a solution of (3-(1-(2-fluorophenyl)-2-nitroethyl)-1H-indol-6-yl)(morpholino)methanone (0.3659 g, 0.921 mmol) in MeOH (30.7 mL). The reaction was shaken under hydrogenation at 53 psi for 3 hr. After flushing with nitrogen, the mixture was filtered through a pad of CELITE® and rinsed with MeOH. The filtrate was concentrated in vacuo to give the desired product (0.270 g, 0.596 mmol, 64.7% yield).

1. customAfter flushing with nitrogen
2. filtrationthe mixture was filtered through a pad of CELITE®
3. washrinsed with MeOH
4. concentrationThe filtrate was concentrated in vacuo