o-Fluoro-beta-nitrostyrene → 3-(1-(2-Fluorophenyl)-2-nitroethyl)-6-methyl-5-(pyrimidin-5-yloxy)-1H-indole

Participants

Reaction Conditions

Reaction Steps

6-Methyl-5-(pyrimidin-5-yloxy)-1H-indole (0.1783 g, 0.792 mmol) and (E)-1-fluoro-2-(2-nitrovinyl)benzene (0.159 g, 0.950 mmol) were dissolved in CH2Cl2, and the solution was concentrated in vacuo. The residue was heated at 130° C. for 4 hr, and the crude product was purified by flash chromatography using an ISCO 40 g column eluting with 0-5% MeOH/CH2Cl2. Appropriate fractions were collected and concentrated in vacuo to give the desired product (0.1644 g, 0.419 mmol, 52.9% yield) as a tan foam.

Provenance & Evidence