反应详情

A solution of the 3-trifluoromethyl-4-[bis(2-hydroxyethyl) amino]benzonitrile and NaOH (0.8 g, 0.02 mol) in aqueous ethanol (10 ml, 50%) was refluxed for 2 hours. The solution was partitioned between EtOAc (120 ml) and HCl (50 ml, 0.4 M), the aqueous layer washed with EtOAc (3×25 ml), the combined organic layers dried (MgSO4) and evaporated to dryness. The residue was recrystallized from EtOAc to give 0.39 g of white crystals.

1. customThe solution was partitioned between EtOAc (120 ml) and HCl (50 ml, 0.4 M)
2. washthe aqueous layer washed with EtOAc (3×25 ml)
3. dry with materialthe combined organic layers dried (MgSO4)
4. customevaporated to dryness
5. customThe residue was recrystallized from EtOAc