Di-tert-butyl dicarbonate → HCID 58362497, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 4-(6-methoxyquinolin-2-yl)-2-nitrophenyl(methyl)carbamate AS-5332-46: To a solution AS-5332-42 (0.030 g, 0.186 mmol) in THF (3.0 mL) was added Boc anhydride (0.063 g, 0.0.291 mmol) and DMAP (0.012 g, 0.097 mmol). The resulting reaction mixture was heated at 100° C. for 30 min. The volatiles were removed in vacuo and residue was purified on a Combiflash purification system (silica gel, 0-7% EtOAc:DCM) to afford AS-5332-43 as a off white solid (0.040 g, 100%). 1H-NMR (400 MHz, CDCl3) δ: 8.69 (d, J=2.0 Hz, 1H), 8.40 (d, J=8.0 Hz, 1H), 8.16 (d, J=8.8 Hz, 1H), 8.07 (d, J=9.2 Hz, 1H), 7.85 (d, J=8.8 Hz, 1H), 7.44 (d, J=8.0 Hz, 1H), 7.41 (dd, J=9.2, 2.8 1H), 7.10 (d, J=2.8 Hz, 1H), 3.95 (s, 3H), 3.34 (s, 3H), 1.32 (s, 9H); MS (ESI): 410.1 (M+H+).

Provenance & Evidence