2-Fluoroethyl bromide → HCID 58362400, compound

Participants

Reaction Steps

General experimental procedure (E) for N-alkylation reaction with 1-bromo-2-fluoroethane was followed. Reaction was performed on a 10.0 mg scale of 3-(4-methoxyphenyl)-1-oxo-1H,5H-pyrido[1,2-a]benzimidazole. Isolated 3.8 mg (33%) of T626 as a white solid. 1H NMR (CDCl3): δ 8.84 (1H, d, J=8.0 Hz), 7.62 (2H, m), 7.45 (1H, m), 7.31 (2H, m), 6.97 (2H, m), 6.54 (1H, s), 6.28 (1H, s), 4.90 (1H, t, J=4.8 Hz), 4.79 (1H, t, J=4.8 Hz), 4.52 (1H, t, J=4.8 Hz), 4.46 (1H, t, J=4.8 Hz), 3.84 (3H, s); MS: 337 (M+H+).

Provenance & Evidence